BMS-8 抑制PD-1/PD-L1相互作用(IC50:7.2 μM)。它能够直接与 PD-L1 结合，促使形成 PD-L1 同源二聚体，进而阻断 PD-L1 与 PD-1 的相互作用。

BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.

BMS-8 has a more stable binding mode with one PD-L1 monomer than the other and the small-molecule inducing PD-L1 dimerization was further stabilized by the non-polar interaction of Ile54, Tyr56, Met115, Ala121, and Tyr123 on both monomers and the water bridges involved in ALys124[2].

1675201-90-7

C27H28BrNO3

494.42

DMSO:60 mg/ml (121.35 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years