C 021 dihydrochloride 是一种 CC 趋化因子受体 4 (CCR4) 拮抗剂，抑制人和小鼠的功能趋化性，IC50分别为 140 和 39 nM。C-021 可有效阻止人 CCL22 衍生的 [35S]GTPγS 与受体结合，IC50为 18 nM。

C 021 dihydrochloride is a potent CCR4 antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 nM, respectively. It effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM).

864289-85-0

C27H41N5O2

467.65

4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years