ThalIDOmide 4-fluoride 是一种基于 ThalIDOmide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。

Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

835616-60-9

C13H9FN2O4

276.223

E3 ligase Ligand 4;2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮

DMSO:199 mg/mL (720.44 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years