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CA-4948
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CA-4948图片
CAS NO:1801344-14-8
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Emavusertib
产品介绍
Emavusertib 是一种IRAK4抑制剂,也是一种FLT3抑制剂,具有抗肿瘤作用。

产品描述

Emavusertib is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.

体外活性

CA-4948, demonstrated good cellular activity in ABC DLBCL and AML cell lines.?Inhibition of TLR signaling leading to decreased IL-6 levels was also observed in whole blood assays.?CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.?CA-4948 was well tolerated in toxicity studies in both mouse and dog at efficacious exposure.?The overall profile of CA-4948 prompted us to select it as a clinical candidate for evaluation in patients with relapsed or refractory hematologic malignancies including non-Hodgkin lymphoma and acute myeloid leukemia[2].

Cas No.

1801344-14-8

分子式

C24H25N7O5

分子量

491.508

别名

Emavusertib

储存和溶解度

DMSO:27.78 mg/mL (56.52 mM),Need ultrasonic
H2O:< 0.1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years