CIL56 是一种选择性铁死亡诱导剂，可通过产生铁依赖性活性氧来诱导细胞铁死亡。

CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death.

300802-28-2

C23H27N3O5S2

489.6

CA3

DMSO:88 mg/mL(179.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years