Procyanidin B2 是天然黄酮类物质，具有抗肿瘤，抗氧化等活性。

Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway.

Procyanidin B2 exerts both antioxidant and pro-oxidant properties by interacting with H2O2 and metal ions[1].

Procyanidin B2 from cinnamon inhibited AGE accumulation in diabetic rat kidney and ameliorated AGE mediated pathogenesis of DN[2].

Streptozotocin-induced diabetic rats were fed with either 3% cinnamon or 0.002% Procyanidin B2(PCB2)-fraction in diet for 12weeks. Biochemical analysis of blood and urine was performed at the end of experiment. Evaluation of glomerular markers that serve as indicators of renal function was done by immunohistochemistry, immunoblotting and qRT-PCR. Supplementation of diabetic rats with cinnamon and PCB2-fraction prevented glycation mediated RBC-IgG cross-links and HbA1c accumulation in diabetes rats. Cinnamon and PCB2-fraction also inhibited the accumulation of N-carboxy methyl lysine (CML), a prominent AGE in diabetic kidney[2].

29106-49-8

C30H26O12

578.526

原花青素 B2;Proanthocyanidin B2

DMSO:50 mg/mL (86.43 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years