MolsIDOmine是一种长效的、口服活性的血管扩张药，在肝脏中代谢可被为活性代谢物LinsIDOmine。 其中LinsIDOmine是一种不稳定的化合物，能够产生NO，可用作血管舒张剂。

Molsidomine is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart[1].

25717-80-0

C9H14N4O4

242.235

吗多明;SIN-10;Morsydomine;Corvaton

DMSO:45 mg/mL (185.8 mM)
Ethanol:21 mg/mL(86.7 mM)
H2O:9 mg/mL (37.15 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years