C-176 是干扰素基因刺激受体的一种强效共价抑制剂。

C-176 is a strong, covalent mouse STING inhibitor

C-176 significantly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6.

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.

314054-00-7

C11H7IN2O4

358.091

STING inhibitor 1;C176

DMSO:100 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years