CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂，pIC50值为9.3。

CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.

CXCR2 plays an important role in the activation and recruitment of neutrophils to the site of inflammation. CXCR2-IN-1 showed good central nervous system penetration characteristics (Br / Bl>0.45)[1].

CXCR2-IN-1 has shown efficacy in oral copper ketone-induced demyelination models by oral administration, providing evidence to support CXCR2 as a potential therapeutic target for the treatment of demyelinating diseases such as multiple sclerosis[1].

1873376-49-8

C19H20Cl2FN3O4S

476.35

DMSO:4.5mg/mL (9.4mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years