Muramyl dipeptide是合成的免疫反应肽，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子，也是NLRP1激动剂。

Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation through a decreased RANKL/OPG ratio. Muramyl dipeptide directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2 .

Muramyl dipeptide (0.1-10 μg/mL; 6 hours) increases mRNA levels of Runx2 in a dose-dependent manner. Muramyl dipeptide (0.1-10 μg/mL; 24 hours) enhances protein expression of Runx2 in a dose-dependent manner .

Muramyl dipeptide (1.25 mg/kg; i.p.; twice) decreases bone loss caused by osteoporosis.

53678-77-6

C19H32N4O11

492.48

MDP;佐剂肽

DMSO:98 mg/mL (198.99 mM)
H2O:98 mg/mL (198.99 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years