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4-hydroxyphenyl acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-hydroxyphenyl acetate图片
CAS NO:3233-32-7
包装与价格:
包装价格(元)
50 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
4-hydroxyphenyl acetate 通过作为 Nrf2 稳定剂防止 RPE 氧化应激诱导的坏死。

产品描述

4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer

体外活性

4-AC is a natural antioxidant, which demonstrates strong abilities to protect RPE cells from oxidative stress-induced necrosis. Mechanistically, 4-AC blocked the increase of cellular ROS induced by oxidative stress, and upregulated NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor. The NQO1, HO-1, and NRF2 were further shown to be required for 4-AC protection of RPE cells from death induced by tBHP. The tBHQ, an NRF2 stabilizer, consistently mimicked the protective effect of 4-AC against tBHP-induced RPE death[1].

Cas No.

3233-32-7

分子式

C8H8O3

分子量

152.149

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years