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ML385
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML385图片
CAS NO:846557-71-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
ML385是一种新型选择性Nrf2抑制剂,IC50为1.9 μM。

产品描述

ML385 is a new-type and selective NRF2 inhibitor.

体外活性

ML385 reduce the NRF2 transcriptional activity in a dose-dependent manner with the maximum inhibitory concentration is 5 μM. ML385 interacts with NRF2 and affects the DNA binding activity of the NRF2-MAFG protein complex(IC50=1.9 μM).

体内活性

ML385 in combination with carboplatin leads to a significant reduction in tumor cell proliferation, demonstrated by fewer Ki-67 positive cells. Tumor samples treated with ML385 show a significant reduction in NRF2 protein level and its downstream target genes.

细胞实验

cells are treated with ML385 for 36 h. An equal amount of CellTiter-Blue reagent is added to the wells and the fluorescence is measured after 30 min. The CellTiter-Blue reagent is discarded and the Caspase-Glo (100 μL) reagent is added to the cells and incubated at 37°C for an additional 60-90 min. The resulting luminescence is recorded and the caspase activity is normalized to cell number

动物实验

Mice tumor xenografts are administered intraperitoneally ML385 (30 mg/kg).

Cas No.

846557-71-9

分子式

C29H25N3O4S

分子量

511.6

储存和溶解度

DMSO:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years