GNF351 是芳烃受体 (AhR) 的完全拮抗剂，具有抑制 DRE 依赖性和非依赖性活性的能力。它与结合到 AhR 的光亲和性 AhR 配体竞争，IC50为 62 nM。它在小鼠或人角质形成细胞中的毒性极小。

GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).

After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.

1227634-69-6

C24H25N7

411.5

DMSO:124 mg/mL(301.34 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years