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Esonarimod
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Esonarimod图片
CAS NO:101973-77-7
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
KE-298
产品介绍
Esonarimod 是一种具有抗风湿作用的化合物。

产品描述

Esonarimod is an antirheumatic drug.

体外活性

The IC50 of Esonarimod is 117.5 μg/mL. In RAW264.7 cells, Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO in a dose-dependent manner.

体内活性

After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity decreases rapidly and no tendency towards accumulation is found.

激酶实验

To test enzyme activity of NOS, the lysate from RAW264.7 cells (a protein concentration of 37.5 μg/200 μL) is incubated for 3 h at 37°C with 100 mM of L-arginine in the presence of Esonarimod (KE-298) and the conversion of L-arginine to nitrite is monitored.

细胞实验

For in vitro experiment, Esonarimod (KE-298) is dissolved in ethanol and diluted with culture medium or distilled water.RAW264.7 cells are used in this study. For NO production, RAW264.7 cells [2×105/0.2 mL of RPMI-1640 supplemented by 10% heat inactivated fetal bovine serum (FBS), penicillin G (100 U/mL), and streptomycin (100 μg/mL)] are stimulated with 100 ng/mL of Escherichia coli 026:B6 lipopolysaccharide in the presence of Esonarimod (KE-298) (0, 10, 30, 100, 200, 300 μg/mL) in 96 well plates and incubated 24 h at 37°C in an atmosphere of 5% CO2 in air. After incubation, the supernatants are collected and assayed for nitrite (NO2-) instead of NO[1].

动物实验

Seven-week-old male Wistar rats is administered Esonarimod (5 mg/kg once daily) orally by gastric intubation.

Cas No.

101973-77-7

分子式

C14H16O4S

分子量

280.34

别名

KE-298

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years