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Nepetin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nepetin图片
CAS NO:520-11-6
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
泽兰黄酮
6-甲氧基藤黄菌素
6-Methoxyluteolin
产品介绍
Nepetin 是一种分离自Eupatorium ballotaefoliumHBK 中的天然类黄酮,具有有效的抗炎作用。它在 ARPE-19 细胞中能够抑制IL-6 (IC50:4.43 μM) 、IL-8 (IC50:43.42 μM) 、MCP-1 (IC50:4.17 μM) 的分泌。

产品描述

6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.

体外活性

Using the human basophilic KU812F cells, we assessed the inhibitory effects of 6-Methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcαμRI-mediated allergic reaction. We determined that 6-Methoxyluteolin inhibited anti-FcαμRI α± chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Moreover, the inhibitory effects of 6-Methoxyluteolin on the cell surface expression and the mRNA level of the FcαμRI α± chain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR), respectively.

Cas No.

520-11-6

分子式

C16H12O7

分子量

316.26

别名

泽兰黄酮;6-甲氧基藤黄菌素;6-Methoxyluteolin

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years