TRIM是一氧化氮合酶抑制剂。它在体外能够抑制小鼠小脑 nNOS (IC50:28.2 μM)，以及大鼠肺 iNOS (IC50:27.0 μM)。它拥有抗焦虑以及抗抑郁的能力。

TRIM is an inhibitor of nNOS.

TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM.?TRIM (10-50 mg kg-1) administered i.p. exhibits dose-related antinociceptive activity in the mouse (assessed as inhibition of late phase formalin-induced hindpaw licking behaviour) with an ED50 of 85.8 mumol kg-1.?In contrast, TRIM (50 mg kg-1, i.p.) failed to influence mean arterial blood pressure in the urethane-anaesthetized mouse[1].

25371-96-4

C10H7F3N2

212.175

1-(2-Trifluoromethylphenyl)imidazole;1-(2-三氟甲基苯基)咪唑

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years