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Negletein
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Negletein图片
CAS NO:29550-13-8
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
黄芩素-7-甲醚
Baicalein-7-methylether
7-O-Methylbaicalein
产品介绍
Negletein 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。

产品描述

1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.

Cas No.

29550-13-8

分子式

C16H12O5

分子量

284.267

别名

黄芩素-7-甲醚;Baicalein-7-methylether;7-O-Methylbaicalein

储存和溶解度

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years