Macbecin I 是一种稳定的 HSP90 抑制剂，通过与 ATP 结合位点结合，IC50 为 2 μM 和 Kd 为 0.24 μM。 Macbecin I 具有抗肿瘤和杀细胞活性。
| Cas No. | 73341-72-7 |
| 别名 | Macbecin I; NSC 330499 |
| 化学名 | (4E,6Z,8S,9S,10E,12R,13S,14R,16S,17R)-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate |
| Canonical SMILES | O=C(C(NC1=O)=C2)C([C@@H]([C@@H](C)C[C@H]([C@H]([C@H](C)/C=C(C)/[C@H]([C@H](/C=C\C=C1/C)C)OC(N)=O)OC)OC)OC)=CC2=O |
| 分子式 | C30H42N2O8 |
| 分子量 | 558.67 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Desiccate at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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