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Roxatidine Acetate HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Roxatidine Acetate HCl图片
CAS NO:93793-83-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Roxatidine Acetate HCl 是一种有效的、选择性的、竞争性的和具有口服活性的组胺 H2 受体拮抗剂。
Cas No.93793-83-0
别名盐酸罗沙替丁醋酸酯; HOE 760
化学名[2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate;hydrochloride
Canonical SMILESCC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2.Cl
分子式C19H28N2O4.HCl
分子量384.9
溶解度≥ 19.245mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Roxatidine Acetate Hydrochloride is a specific and competitive histamin H2 receptor antagonist.Target: Histamin H2 ReceptorRoxatidine Acetate Hydrochloride is a histamine H2-receptor antagonist which, after almost complete oral absorption (greater than 95%), is rapidly converted to its active metabolite, roxatidine, by esterases in the small intestine, plasma and liver. Roxatidine Acetate Hydrochloride is a potent inhibitor of basal and stimulated gastric acid secretion in animals and humans and, like most other H2-receptor antagonists, has no anti-androgenic effects and does not interfere with the hepatic metabolism of other drugs [1, 2].

References:
[1]. Murdoch, D. and D. McTavish, Roxatidine acetate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders. Drugs, 1991. 42(2): p. 240-60.
[2]. Pali-Scholl, I. and E. Jensen-Jarolim, Anti-acid medication as a risk factor for food allergy. Allergy, 2011. 66(4): p. 469-77.