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Aceclofenac
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aceclofenac图片
CAS NO:89796-99-6
包装:1mg
市场价:450元

产品介绍
醋氯芬酸是一种口服活性的非甾体抗炎药 (NSAID),具有镇痛和抗炎特性。
Cas No.89796-99-6
别名醋氯芬酸
化学名2-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetoxy)acetic acid
Canonical SMILESClC1=C(NC2=CC=CC=C2CC(OCC(O)=O)=O)C(Cl)=CC=C1
分子式C16H13Cl2NO4
分子量354.18
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.Target: COXAceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac [1].

References:
[1]. Dannhardt G, et al. In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs). Inflamm Res. 2001 May;50(5):262-9.