MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.

MIR96-IN-1 inhibits Drosha cleavage of pri-miR-96, as evidenced by an increase in the levels of pri-miR-96 and a reduction in levels of pre- and mature miR-96 in treated cells, as expected if MIR96-IN-1 binds to the Drosha site. MIR96-IN-1 efficiently and selectively silences production of miR-96 at 40 μM while not affecting miR-182 or -183. MIR96-IN-1 inhibits biogenesis of its target precursor miRNA to varying extents: MIR96-IN-1 reduces the expression level of miR-96 by 90% at 40 μM [1].

1311982-88-3

C33H48N8O2

588.79

DMSO:100 mg/mL (169.84 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years