Vancomycin hydrochloride是Vancomycin的盐酸盐，是一种支链三环糖基化肽，对大多数生物体具有杀菌活性，对肠球菌具有抑菌作用。

Vancomycin Hydrochloride is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci.

Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide that is structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2].

Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is related to improved clinical, diarrhea, and histopathology scores and survival during treatment[3].

1404-93-9

C66H76Cl3N9O24

1485.72

Vancomycin HCl;盐酸万古霉素

H2O:33.33 mg/mL (22.43 mM),Need ultrasonic
DMSO:24 mg/mL (16.15 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years