Imeglimin hydrochloride 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性，能够抑制活性氧的产生、增加线粒体 DNA、改善线粒体功能。

Imeglimin hydrochloride prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.

Imeglimin dramatically decreased reactive oxygen species production, inhibiting specifically reverse electron transfer through complex I. Imeglimin prevents hyperglycemia-induced cell death in HMEC-1 through inhibition of PTP opening without inhibiting mitochondrial respiration nor affecting cellular energy status[1].

775351-61-6

C6H14ClN5

191.66

(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐;EMD 387008 hydrochloride

DMSO:25 mg/mL (130.44 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years