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Isofraxidin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Isofraxidin图片
CAS NO:486-21-5
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
异嗪皮啶
Phytodolor
6,8-Dimethoxyumbelliferone
异秦皮啶
产品介绍
Isofraxidin 是来自刺五加的香豆素成分,抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞,抑制ERK1/2磷酸化。它减弱iNOS和COX-2表达,还抑制TLR4/髓样分化蛋白 2 复合物的形成。

产品描述

1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.

Cas No.

486-21-5

分子式

C11H10O5

分子量

222.19

别名

异嗪皮啶;Phytodolor;6,8-Dimethoxyumbelliferone;异秦皮啶

储存和溶解度

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:40 mg/mL(180 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years