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Mogroside III-E
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mogroside III-E图片
CAS NO:88901-37-5
包装与价格:
包装价格(元)
10 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
罗汉果皂苷ⅢE
产品介绍
MogROSide IIIe 是一种葫芦烷型化合物,从罗汉果中分离得到,可抑制 NO 的释放,具有抗肺纤维化作用。

产品描述

Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. It also has anti-fibrotic activity, it reduces pulmonary fibrosis through Toll-Like receptor 4 pathways.

体外活性

MG IIIE elevated the cell viability of HG-induced MPC-5 cells, reduced the concentrations of inflammatory cytokines and decreased the levels of oxidative stress-related markers.?What's more, the apoptosis of podocytes induced by HG was inhibited after MG IIIE intervention, accompanied by the upregulated expression of Bcl-2 and downregulated expression of Bax, cleaved caspase-3 and cleaved caspase-9.?It was also found that MG IIIE could activate the AMPK/SIRT1 signaling, but compound C inhibited this pathway and reversed the inhibitory effects of MG IIIE on inflammation, oxidative stress and apoptosis in HG-stimulated podocytes.

Cas No.

88901-37-5

分子式

C48H82O19

分子量

963.15

别名

罗汉果皂苷ⅢE

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years