HBX 41108 是一种泛素特异性蛋白酶 7 的非竞争性抑制剂，IC50为 424 nM。它诱导 p53 依赖的凋亡，抑制 USP7 介导的 p53 去泛素化以稳定 p53 并抑制癌细胞生长。

HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.

924296-39-9

C13H3ClN4O

266.64

7-氯-9-氧代-9H-茚并[1,2-B]吡嗪-2,3-二甲腈;HBX-41108

DMSO:13 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years