Elimusertib hydrochloride(1876467-74-1 free base) 是一种有效的、可口服的、具有抗肿瘤活性的选择性 ATR 抑制剂。

Elimusertib hydrochloride is a effective, orally available and selective ATR inhibitor with anti-tumor activity.

Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines (median IC50: 78 nM). BAY-1895344 potently suppresses NSC-32065-induced H2AX phosphorylation (IC50: 36 nM) [1].

In a variety of xenograft models of ovarian and colorectal cancer, Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy and causes complete tumor remission in mantle cell lymphoma models [2].

T10468

C20H22ClN7O

411.89

BAY-1895344 hydrochloride

DMSO:50 mg/mL (121.39),Need ultrasonic and warming
H2O:48 mg/mL (116.53 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years