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UBCS039
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UBCS039图片
CAS NO:358721-70-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
UBCS039 是一种合成的SIRT6特异性激活剂,可在人癌细胞中诱导自噬,其EC50值为38 μM。

产品描述

UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)

体外活性

UBCS039 induced a time-dependent activation of autophagy in several human tumor cell lines, as evaluated by increased content of the lipidated form of LC3B by western blot and of autophagosomal puncta by microscopy analysis of GFP-LC3.?UBCS039-mediated activation of autophagy was strictly dependent on SIRT6 deacetylating activity since the catalytic mutant H133Y failed to activate autophagy.?At the molecular level, SIRT6-mediated autophagy was triggered by an increase of ROS levels, which, in turn, resulted in the activation of the AMPK-ULK1-mTOR signaling pathway.?Interestingly, antioxidants were able to completely counteract UBCS039-induced autophagy, suggesting that ROS burst had a key role in upstream events leading to autophagy commitment.

Cas No.

358721-70-7

分子式

C16H13N3

分子量

247.301

储存和溶解度

DMSO:125 mg/mL (505.48 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years