TH287 是一种选择性的MTH1抑制剂，对 MTH1 具有高度选择性，可用于治疗癌症的研究。

TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.

TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage. [1]

In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82 μM. [2]

1609960-30-6

C11H10Cl2N4

269.13

TH287 hydrochloride

DMSO:49 mg/mL (160.3 mM)
Ethanol:10 mg/mL (37.15 mM),warmed
Powder: -20°C for 3 years
In solvent: -80°C for 2 years