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Orotic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Orotic acid图片
CAS NO:65-86-1
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
乳清酸
Vitamin B13
6-Carboxyuracil
产品介绍
Orotic acid 是一种嘧啶核苷酸和 RNA 生物合成的前体,从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放,通过细胞质 UMP 合酶转化为 UMP。它可引起大鼠肝脂肪变性和肝肿大,是尿素循环异常的常规新生儿筛查中的一种测量指标。

产品描述

Orotic acid is an intermediate product in pyrimidine metabolism.

体外活性

Orotic acid increases cell proliferation and decreases apoptosis in serum-starved SK-Hep1 hepatocellular carcinoma cells, which may ascribe to the inhibition of AMP-activated protein kinase (AMPK) phosphorylation and thus activation of mammalian target of rapamycin complex 1 (mTORC1) [1].

体内活性

Male Fischer 344 rats (130-150 g) to two-thirds PH in the absence or in the presence of Orotic acid (a 300-mg tablet of Orotic acid methyl ester implanted intraperitoneally at the time of two-thirds PH). treatment with Orotic acid resulted in a near-100% inhibition of RNR induced by two-thirds PH in rat liver, as monitored by enzyme activity and protein level [2]. Feeding 1% Orotic acid with diet decreased the phosphorylation of AMPK and increased the maturation of SREBP-1 and the expression of SREBP-responsive genes in the rat liver. Orotic acid-induced lipid accumulation was also completely inhibited by rapamycin. Mouse hepatocytes and mice were resistant to Orotic acid-induced lipogenesis because of little if any response in AMPK and downstream effectors [3].

Cas No.

65-86-1

分子式

C5H4N2O4

分子量

156.097

别名

乳清酸;Vitamin B13;6-Carboxyuracil

储存和溶解度

DMSO:12.8 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years