Treosulfan是一种双功能的烷化剂，对卵巢癌及其他的实体瘤都有抑制效果。

Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.

Treosulfan inhibits several cancer cell lines, such as Panc-1, Miapaca-2 and Capan-2 cells (IC50s: 3.6 μg/mL, 1.8 μg/mL and 2.1 μg/mL respectively). It also shows nearly 100% cytotoxicity on these cell lines at 100 μg/mL. Treosulfan (1, 2.5, 5 μg/ml) combined with 5-FU (0.1, 0.25, 0.5 μg/ml) has antagonistic effect on Panc-1 cells at intermediate and high concentrations, and on Miapaca-2 cells at all doses. Treosulfan (0.1-100 μg/mL) in combination with LY 188011 exhibits enhanced activity against cancer cells. Treosulfan (800 μg/mL) dramatically decreases erythrocyte forward scatter, increases the percentage of annexin-V-binding cells, [Ca2+]i, and ROS [1][2].

Treosulfan (1.5 g/kg/day) induces only interleukin-2 production in spleen cells for a short time. Treosulfan (1.5 g/kg/day) causes a rapid myeloablation, depletes the splenic B and T cells in mice [3].

299-75-2

C6H14O8S2

278.3

曲奥舒凡;NSC 39069;Treosulphan

DMSO:100 mg/mL (359.32 mM)
H2O:50 mg/mL (179.66 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years