AP-1/NF-Κb activation inhibitor 1 是一种有效的AP-1和NF-Κb介导的转录激活抑制剂(IC50=1 μM)，不阻断 β-actin 启动子驱动的基础转录。AP-1/NF-Κb activation inhibitor 1 对受刺激细胞中IL-2和IL-8的产生水平有相似的抑制作用。

AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells [1].

188936-12-1

C13H11F3N4O4

344.25

DMSO:225mg/mL (653.6mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years