Cytarabine hydrochloride 是一种核苷类似物，可导致 S 期细胞周期停滞并抑制DNA聚合酶。Cytarabine 抑制DNA 合成，IC50为 16 nM。Cytarabine hydrochloride对HSV具有抗病毒作用。

Cytarabine hydrochloride is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC 50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.

Cytarabine is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidine kinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNA synthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a higher growth inhibitory activity towards wild-type CCRF-CEM cells with IC 50 of 16 nM compared to other acute myelogenous leukemia (AML) cells [1]. Cytarabine apparently induces apoptosis of rat sympathetic neurons at 10 μM, of which 100 μM shows the highest toxicity and kills over 80% of the neurons by 84 hours, involving the release of mitochondrial cytochrome-c and the activation of caspase-3, and the toxicity can be attenuated by p53 knockdown and delayed by bax deletion [2].

Cytarabine (250 mg/kg) also leads to placental growth retardation and increases placental trophoblastic cells apoptosis in the placental labyrinth zone of the pregnant Slc:Wistar rats, which increases from 3 hour after the treatment and peaks at 6 hour before returning to control levels at 48 hour, with remarkably enhanced p53 protein, p53 trancriptional target genes such as p21, cyclinG1 and fas and caspase-3 activity [3]. Cytarabine is highly effective against acute leukaemias, which causes the chCytarabineteristic G1/S blockage and synchronization, and increases the survival time for leukaemic Brown Norway rats in a weak dose-related fashion indicating that the use of higher dosages of Cytarabine does not contribute to its antileukaemic effectiveness in man [4].

69-74-9

C9H14ClN3O5

279.68

Cytosine Arabinoside hydrochloride;Ara-C hydrochloride

DMSO:45mg/mL (160.9mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years