PACOCF3 (PalmityLTRifluoromethylketone) 是一种钙非依赖性的磷脂酶 A2 (Phospholipase A2) 抑制剂，IC50为 3.8 μM。PACOCF3 改变肾小管细胞中的 Ca2+信号传导。

PACOCF3 (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2].

PACOCF3 does not change basal cytosolic free calcium concentrations ([Ca 2+ ] i ) at a concentration of 20 μM, while at concentrations of 50-250 μM PACOCF3 induced an increase in [Ca 2+ ] i by activating extracellular Ca 2+ entry which is partly suppressed by 50 μM La3+ [2]. The effect of PACOCF3 is abolished by removal of extracellular Ca 2+. PACOCF3 (10 μM) enhances both the peak value and the area under the curve of the [Ca 2+ ] i increase induced by 10 μM ATP and 1 μM bradykinin by potentiating extracellular Ca 2+ influx without affecting internal Ca 2+ release [2].

141022-99-3

C17H31F3O

308.42

Palmityltrifluoromethylketone;1,1,1-trifluoroheptadecan-2-one

DMSO:31.5mg/mL (102.1mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years