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Atosiban
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Atosiban图片
CAS NO:90779-69-4
包装:10 mg
市场价:995元

产品名称
阿托西班
RW22164
RWJ22164
产品介绍
Atosiban 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。

产品描述

Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.

Cas No.

90779-69-4

分子式

C45H71N11O14S2

分子量

994.19

别名

阿托西班;RW22164;RWJ22164

储存和溶解度

DMSO:16.67 mg/mL (16.77 mM)
H2O:16.67 mg/mL (16.77 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years