ML339 是有效的CXCR6选择性拮抗剂，IC50为 140 nM。ML339 对 CXCR5，CXCR4，CCR6 和 Apelin 受体 (APJ) 无拮抗作用，IC50>79 μM。ML339 在前列腺癌研究领域有研究的价值。

ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.

The murine assay was validated using anti-mCXCR16 as an antagonist positive control tested in the presence of an EC80 concentration of mCXCL16 (IC50 = 1.5 nM; % response = 100%). Probe ML339 was shown to be 100-fold less active at the murine CXCR6 receptor using the DiscoveRx β-arrestin cell-based assay format[1].

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DMSO:125 mg/mL (249.00 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years