AS-0141 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性，详情请参考文献 WO2019165473A1，compound I-D。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。

AS-0141 is a potent Cdc7 kinase inhibitor (IC50=4 nM) extracted from patent WO2019165473A1(compound I- D) with anti-tumor activity.

AS-0141 shows potent inhibitory activity (IC50<3 μΜ) in a range of solid tumor cell lines, including those of sarcoma (143B, CADO-ES1, RD-ES, A673), bladder (5673, RT1 12/84), colon and cecum (Colo-205, DLD-l, LS1034, SK-CO-l, SNU-C1), renal (U0.31), melanoma (A2058, A875), head-and-neck (CNE-2Z, RPMI-2650), and gastric (HGC-27) lineages[1].

1402057-88-8

C21H22F3N5O4

465.43

PNT-141;Cdc7-IN-6;SRA-141

DMSO:76.5mg/mL (164.4mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years