Clocapramine dihydrochloride hydrate 是多巴胺 D2 和 5-HT2A 受体拮抗剂。

Clocapramine dihydrochloride hydrate is an antagonist of the 5-HT2A and D2 receptors.

Clocapramine shows the lowest potency for D2-occupancy in vivo [1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50s: 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2) [2].

60789-62-0

C28H41Cl3N4O2

572.01

3-Chlorocarpipramine hydrochloride hydrate;Clocapramine hydrochloride hydrate

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years