APTSTAT3-9R acetate 是一种特异性肽结合 STAT3，具有抗增殖和抗肿瘤活性。 APTSTAT3-9R acetate 并通过特异性阻断 STAT3 磷酸化来抑制 STAT3 活化和下游信号传导。

APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity. APTSTAT3-9R acetate and inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation.

APTSTAT3-9R acetate (7.5, 15, and 30 μmol/L) significantly reduces STAT3–DNA-binding activity in a dose-dependent manner in human lung carcinoma cells (A549) but does not affect the level of AKT phosphorylation, indicating specificity of the aptide. APTSTAT3-9R acetate (30 μM) suppresses cell viability and proliferation of cancer cells and significantly suppresses colony formation. The IC50s are 10 to 20 μM in A549, B16F1, and HepG2 cells[1].

In female BALB/c nude mice with A549 cells, APTSTAT3-9R acetate (8 mg/kg in 50 μL; intratumoral injection) suppresses tumor growth[1].

TP2222L

C225H334N80O53

5007.56

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years