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Cannabidiol dimethyl ether
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cannabidiol dimethyl ether图片
CAS NO:1242-67-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Cas No.1242-67-7
别名CBDD,Cannabidiol-2',6'-dimethyl ether
化学名1,3-dimethoxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-benzene
Canonical SMILESCCCCCc1cc(OC)c(c(OC)c1)[C@@H]1C=C(C)CCC1C(=C)C
分子式C23H34O2
分子量342.5
溶解度≤14mg/ml in ethanol;1mg/ml in DMSO;2mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cannabidiol dimethyl ether (CBDD) is a cannabidiol derivative that potently and selectively inhibits 15-LOX with an IC50 value of 0.28 μM.

15-LOX can oxygenate cholesterol esters in the low-density lipoprotein (LDL) particle. Thus, 15-LOX has been involved in the development of atherosclerosis, and CBDD may be a useful prototype for producing medicines for atherosclerosis [1].

CBDD showed a potent inhibitory effect on the catalytic activity of cytochrome P450 2C19 with an IC50 value of 14.8 μΜ [2]. CBDD inhibited the CYP2B6 activity with the IC50values of 75.7 μM [3]. Cytochrome P450 enzymes have been isolated from numerous mammalian tissues such as liver, kidney, lung, intestine, adrenal cortex. Cytochrome P450 enzymes have also existed in insects, plants, yeasts, and bacteria. Cytochrome P450 has been known to catalyze hydroxylations, epoxidations, N-, S-, and O-dealkylations, N-oxidations, sulfoxidations, dehalogenations, and other reactions [4].

References:
[1] Takeda S, Usami N, Yamamoto I, et al.  Cannabidiol-2′, 6′-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor[J]. Drug Metabolism and Disposition, 2009, 37(8): 1733-1737.
[2] Jiang R, Yamaori S, Okamoto Y, et al.  Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19[J]. Drug metabolism and pharmacokinetics, 2013, 28(4): 332-338.
[3] Yamaori S, Maeda C, Yamamoto I, et al.  Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids[J]. Forensic Toxicology, 2011, 29(2): 117-124.
[4] Groves J T, Han Y Z.  Models and mechanisms of cytochrome P450 action[M]//Cytochrome P450. Springer US, 1995: 3-48.