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Quetiapine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Quetiapine图片
CAS NO:111974-69-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议

产品介绍
Quetiapine (ICI204636) 是一种 5-HT 受体激动剂,对人 5-HT1A 受体的 pEC50 为 4.77。
Cas No.111974-69-7
别名喹硫平; ICI204636
化学名2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol
Canonical SMILESC1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42
分子式C21H25N3O2S
分子量383.51
溶解度≥ 19.2 mg/mL in DMSO, ≥ 29.55 mg/mL in EtOH with gentle warming
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

Quetiapine (ICI204636) is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine (ICI204636) also has an antagonistic effect on the histamine H1 receptor.

References:
[1]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.