Ethylhydrocupreine hydrochloride 是的奎宁一种衍生物，具有抗菌作用，可抑制肺炎链球菌的活性。它还具有抗疟活性，抗PlaSmodium falciparum的IC50为 25.75 nM。它是Gallus gallus2 受体 (ggTas2r1，ggTas2r2和ggTas2r7) 激动剂。

Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum , with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is an agonist of Gallus gallus taste 2 receptors ( ggTas2r1 , ggTas2r2 and ggTas2r7 ).

The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains ( S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). For all three strains studied, the exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold [2].

The highest tolerated dose of ethylhydrocupreine hydrochloride for guinea pigs by intrapleural injection is about 0.2 to 0.3 cc. of a 1:100 solution per 100 gm. of weight, corresponding to 2 to 3 cc. of solution or 0.02 to 0.03 gm. of the drug per kilo of weight. The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs [1] .

3413-58-9

C21H29ClN2O2

376.92

Optochin hydrochloride;乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐

H2O:50 mg/mL (132.65 mM),Need ultrasonic
DMSO:125 mg/mL (331.64 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years