DPH是一种有效的细胞渗透的c-Abl激活剂。DPH在刺激c-Abl活化方面显示出强大的酶活性和细胞活性。

DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular activity in stimulating c-Abl activation.

DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation. DPH binds to the myristoyl binding site. It also prevents the formation of the bent conformation of the αI helix through steric hindrance. Which is a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site [1].

484049-04-9

C18H13FN4O2

336.32

DMSO:90mg/mL (267.6mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years