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Loxiglumide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Loxiglumide图片
CAS NO:107097-80-3
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
氯谷胺
CR-1505
产品介绍
Loxiglumide 是一种缩胆囊素受体拮抗剂。

产品描述

Loxiglumide is an antagonist of cholecystokinin (CCK-1) receptor.

激酶实验

Kinase binding assays: For optimization of Axl/TAM receptor inhibitors, an Axl binding assay is established (HTRF method; Kinase tracer 236). This assay is based on the binding and displacement of the Alexa Fluor 647-labelled Kinase tracer 236 to each glutathione S-transferase (GST)-tagged kinase used in the binding assay. Binding of the tracer to the kinase was detected by using europium (Eu)-labelled anti-GST antibodies. Simultaneous binding of both the fluorescent tracer and the Eu-labelled antibodies to the GST-tagged kinase generates a fluorescence resonance energy transfer (FRET) signal. Binding of inhibitor to the kinase competes for binding with the tracer, resulting in a loss of the FRET signal. For the assay, the compound is diluted in 20?mM HEPES, pH?8.0, 1?mM DTT, 10?mM MgCl2 and 0.01% Brij35. Then, the kinase of interest (5?nM final concentration), fluorescent tracer (15?nM final concentration) and LanthaScreen Eu-anti-GST antibody (2?nM final concentration) are mixed with the respective compound dilutions (from 5?nM to 10?μM) and incubated for 1?h. The FRET signal is quantified using an EnVision Multilabellreader 2104.

Cas No.

107097-80-3

分子式

C21H30Cl2N2O5

分子量

461.38

别名

氯谷胺;CR-1505

储存和溶解度

DMSO:>10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years