PLX-5622 是一种选择性的、高效的、能透过血脑屏障的、口服具有活性的CSF1R抑制剂 (IC50= 0.016 μM;Ki= 5.9 nM)，具有较好的药理学特性，可用于病程发展前和过程中，扩大的和特异性的小胶质细胞的消除。

PLX-5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.

Treated pregnant dams with the CSF1R inhibitor PLX-5622. Approximately 99% of microglia were eliminated by embryonic day 15.5 (E15.5) after pregnant dams were placed on a PLX-5622 diet starting at E3.5. Following microglia depletion, Elevated numbers of apoptotic cells accumulating throughout the developing hypothalamus. Once the PLX-5622 diet was removed, microglia repopulated the postnatal brain within 7?days and did not appear to repopulate from Nestin+?precursors[1].

1303420-67-8

C21H19F2N5O

395.414

PLX-5622

DMSO:79 mg/mL (199.79 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years