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Cycloastragenol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cycloastragenol图片
CAS NO:78574-94-4
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
环黄芪醇
Cyclogalegenol
Astramembrangenin
产品介绍
Cycloastragenol 是一种三萜皂苷类化合物,是黄芪主要活性成分的水解产物,具有抗氧化、抗炎、抗衰老、抗凋亡和心血管保护作用。它是端粒酶激活剂,可以延长端粒,还能缓解与年龄相关的骨丢失,改善骨微结构和生物力学特性。

产品描述

Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression

体外活性

Cyclogalegenol has important anti-inflammatory activity by inhibiting lymphocytes activation, proliferation and cytokines expression, this effect may be related to reduction of overall intracellular Ca2+ overload[1].

体内活性

oral administration of Cyclogalegenol for 7 days attenuated depression-like behavior in experimental mice.Cyclogalegenol stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Furthermore, Cyclogalegenol may have a novel therapeutic role in depression[2].

细胞实验

Mouse lymphocytes were obtained from spleens and subjected to Con A for 24?h. Herein, the cells were treated with different concentrations of Cyclogalegenol. Cell viability was assayed by MTT. Pretreated by Cyclogalegenol?and stimulated?by Con A,?the expression of CD69 and CD25, Th1/Th2/Th17 cytokines, cell cycle, proliferation and intracellular Ca2+ concentration ([Ca2+]i) were analyzed by flow cytometry[1].

动物实验

Mice were administered Cyclogalegenol?100 mg/kg, or water by oral gavage, or imipramine 15 mg/kg , a currently?used tricyclic antidepressant, by intraperitoneal injection for 7 days as well as 45 min before testing.?The forced swim test was performed as described previously , by placing a mouse in a glass cylinder (height: 30 cm, diameter: 15 cm) filled with water to a depth of 12 cm.?Mice were tested in the cylinder for 6 min. The water was changed before testing another animal.?All test sessions were recorded.?Depression-like behavior was determined by observing the immobility of the mouse, where immobility is defined as when a mouse floats passively in the water with minimal movement to keep its head above the water.?The total period of immobility during the last 4 min of the test session was determined[2].

Cas No.

78574-94-4

分子式

C30H50O5

分子量

490.72

别名

环黄芪醇;Cyclogalegenol;Astramembrangenin

储存和溶解度

DMSO:98 mg/mL (199.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years