Adefovir 是一种单磷酸腺苷类似物抗病毒剂，在细胞内转化为 Adefovir diphosphate 后可抑制HBVDNA聚合酶。它在 HepG2.2.15 细胞系中对HBV的IC50为 0.7 μM。它对多种病毒(包括HBV和疱疹病毒)具有良好的抗病毒活性。

Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

adefovir is a potent inhibitor of DHBV replication that inhibits CCC DNA amplification but does not effectively prevent the formation of CCC DNA from incoming viral genomes[1].

The effect of adefovir on viral CCC DNA synthesis was examined with primary cultures of DHBV-infected fetal hepatocytes.?Adefovir was administered for six consecutive days starting one day before or four days after DHBV inoculation.?Dose-dependent inhibition of both virion release in culture supernatants and synthesis of intracellular viral DNA was observed[1].

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C8H12N5O4P

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