MI-2-2 是一种抑制 menin 和 MLL 之间二价蛋白质-蛋白质相互作用的抑制剂，IC50 为 46 nM。 MI-2-2 与 menin 结合，Kd 为 22 nM。

MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.

MI-2-2 is capable of inhibiting the bivalent fragment of MLL that comprises both MBM1 and MBM2 with IC50 of 520 nM. MI-2-2 potently inhibits cell proliferation, differentiation and down-regulation of Hoxa9 expression. MI-2-2 exhibits pronounced activities at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4[1].

1454920-20-7

C17H20F3N5S2

415.5

MI22;MI 2 2

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years