N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamIDO)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide是一种强效的、选择性的Enhancer of Zeste Homolog 2 (EZH2),对EZH2 WT和EZH2-Y641F的IC50分别为37.6nM和79.1nM。
产品描述
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and selective Enhancer of Zeste Homolog 2 (EZH2) inhibitor with IC50 0f 37.6 nM and 79.1 nM for EZH2 WT and EZH2-Y641F, respectively.
体外活性
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide exhibits antiproliferative effects against the WSU-DLCL2 cell line with GI50 of 0.2 μM.
Cas No.
2238820-26-1
分子式
C32H38N4O4
分子量
542.67
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years