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Vedaprofen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vedaprofen图片
CAS NO:71109-09-6
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
CERM 10202
维达洛芬
Quadrisol
产品介绍
Vedaprofen 抑制 COX-1 并通过抗炎活性减少前列腺素 H2 的合成。 Vedaprofen 是一种大肠杆菌滑动钳抑制剂,IC50 为 222 μM,Ki 为 131 μM。

产品描述

Vedaprofen inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM.

体外活性

Vedaprofen blocks the activity of the E. coli DNA polymerase III β subunit, preventing DNA replication and repair[1]. Vedaprofen inhibits horse serum TxB2 and horse exudate PGE2 with IC50s of 9 ng/mL and 630 ng/mL, respectively[3].

体内活性

In beagle dogs, the absorption of Vedaprofen (0.5 mg/kg; oral) was rapid (tmax 0.63 h) and almost complete (bioavailability 86%). The terminal half-lives after intravenous and oral administration, 16.8 and 12.7 h respectively, were of the same order of magnitude. Vedaprofen does not accumulate in plasma[2].

Cas No.

71109-09-6

分子式

C19H22O2

分子量

282.38

别名

CERM 10202;维达洛芬;Quadrisol

储存和溶解度

DMSO:10 mg/mL
Ethanol:10 mg/mL
DMF:25 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years